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- 產(chǎn)品名稱： DM1
- 產(chǎn)品貨號： CS00037
- 貨期： 現(xiàn)貨
- 價格與訂購： 920
- 數(shù)量：
庫存： 10
- 規(guī)格： 10mg
- 產(chǎn)品信息
- 如何訂購
產(chǎn)品描述
Mertansine refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. Experimental ADCs with the SPP-DM1 design include lorvotuzumab mertansine.
靶點活性
Others
別名
化合物Mertansine , Maytansinoid DM1 , DM1
純度
98%
分子量
738.29
分子式
C35H48ClN3O10S
CAS No.
139504-50-0
存儲
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
溶解度
H2O: < 0.1 mg/mL (insoluble)
DMSO: 83.33 mg/mL (112.87 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
參考文獻
1. Whiteman KR, et al. MAbs. 2014 Mar-Apr;6(2): 556-66.
2. Wang Y Q, Ji M Y, Wang C. Endoplasmic reticulum-targeted glutathione and pH dual responsive vitamin lipid nanovesicles for tocopheryl DM1 delivery and cancer therapy[J]. International Journal of Pharmaceutics. 2020: 119331.
Note
For research use only .
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